Oxygen at the Final Frontier: Advances in the Assessment of Aerobic Function in Health and Disease

About this course

Aerobic capacity is the strongest predictor of morbidity, mortality, and quality of life. This course will describe advances in our understanding of the O2 cascade and O2 utilization limitations affecting aerobic capacity in health and chronic disease. An overview of the O2 cascade, emphasizing discoveries from animal models that have set the foundation for human studies, will set the scene. Next, an innovative, non-invasive, near infrared spectroscopy (NIRS) methodology to investigate human skeletal muscle oxidative capacity will be described. The third complementary talk will describe an innovative evolution of the NIRS technique to measure skeletal muscle O2 diffusing capacity and intramuscular O2 flux limitations. The final presentation will describe the integration of oxidative and O2 diffusing capacity that determines neuromuscular performance limits and assessment using a new "muscle" cardiopulmonary exercise test. The concluding panel discussion will focus on the practical application of these methodological advancements to better understand performance limits.

What you will learn

• Define the steps and potential limitation of the O2 cascade pathway (i.e., from mouth to mitochondria) in determining skeletal muscle oxidative capacity
• Describe the principles and characteristics of skeletal muscle oxidative capacity and O2 diffusing capacity changes in health and chronic disease in individuals
• Summarize the main features of new techniques assessing skeletal muscle oxidative capacity, O2 diffusing capacity, and neuromuscular performance

Save when you bundle

• Recertification Booster: 15 CECsReach 15 CECs, 15% off
  Build this pack →
• Full Renewal: 45 CECsReach 45 CECs, 25% off
  Build this pack →