Journal CE · 1 CEC

microRNA-1: A Master Regulator of Metabolism Governing Skeletal Muscle Hypertrophy

Discover the emerging role of microRNA-1 (miR-1) as a key regulator of skeletal muscle growth and metabolism. This course explores the latest research demonstrating how exercise- and overload-induced reductions in miR-1 drive metabolic reprogramming that supports muscle hypertrophy. Participants…

About this course

Exercise and Sport Sciences Reviews, Volume 54 • Number 3 • July 2026 | DOI: 10.1249/JES.0000000000000384

What you will learn

  • Explain the role of microRNA-1 (miR-1) in regulating skeletal muscle hypertrophy and metabolic adaptation during mechanical overload and resistance exercise
  • Describe how decreased miR-1 expression promotes metabolic reprogramming toward aerobic glycolysis through its regulation of pyruvate metabolism genes
  • Discuss the local and systemic effects of miR-1, including its influence on skeletal muscle growth and its extracellular vesicle–mediated communication with adipose tissue

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